The film was also a commercial failure, grossing $14 million worldwide against a $70 million budget. It received mixed reviews from critics, who praised the world building, the animation, story, and voice performances, but criticized the inconsistent tone of the live-action portions and overuse of gross-out humor. The film premiered on August 7, 2001, and was released theatrically three days later. It follows the title character, an anthropomorphic white blood cell, as he teams up with a cold pill to protect his unhealthy human host from a villainous virus. Combining live-action sequences directed by the Farrelly brothers and animation directed by Piet Kroon and Tom Sito, the film stars the voices of Chris Rock, Laurence Fishburne, David Hyde Pierce, Brandy Norwood, and William Shatner alongside Molly Shannon, Chris Elliott, and Bill Murray in live-action roles. However, when Bob Daley, who ran the studio at the time, saw the balloon, he thought that a misshapen Mickey Mouse (who was owned by Disney, Warner's rivals at the time) was sitting on top of the tower and he demanded it be removed.Osmosis Jones is a 2001 American live-action/animated action comedy film written by Marc Hyman.

An inflatable balloon of the character was made once to promote the original show, sitting on top of the water tower.

Yakko is some level of lactose intolerant.

His idol is famous actress Michelle Pfeiffer (who in the series was portrayed in the Catwoman outfit she wore in Batman Returns).

In some episodes, he is seen writing with his left hand, and in others, he is seen writing with his right hand.

In an interview with Tom Ruegger in Talkin' Toons With Rob Paulsen episode 14, he states that Yakko is 14 years old.

His design is also based on the 2020 Hulu reboot, though his head is significantly darker than the rest of his body. The pants are held up by a large black belt with a golden square buckle. He wears a pair of smoky topaz slack pants that go up to his waist.

Yakko has primarily black fur with a red nose and white face and feet.

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